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CRAVIT injection should only be administered by intravenous infusion. It is not for intramuscular, intrathecal, intraperitoneal, or subcutaneous administration.
Caution: Rapid or bolus intravenous infusion must be avoided. Levofloxacin injection should be infused intravenously slowly over a period of not less than 60 or 90 minutes, depending on the dosage. (See PRECAUTIONS.)
The usual dose of CRAVIT tablet is 250 mg - 750 mg administered orally every 24 hours, as indicated by infection and described in following dosing chart. The usual dose of CRAVIT injection is 250 mg or 500 mg administered by slow infusion over 60 minutes every 24 hours or 750 mg administered by slow infusion over 90 minutes every 24 hours, as indicated by infection and described in the following dosing chart. These recommendations apply to patients with normal renal function (i.e., creatinine clearance > 80 mL/min).
For patients with altered renal function, see the patients with impaired renal function subsection. Oral dose should be administered at least two hours before or two hours after antacids containing magnesium, aluminium, as well as sucralfate, metal cations such as iron, and multivitamin preparations with zinc or didanosine, chewable/buffered tablets or the pediatric powder for oral solution.
Patients with normal renal function: See Table 1.
Click on icon to see table/diagram/imageIt is usually possible to switch from initial intravenous treatment to the oral route after a few days, according to the condition of the patient.
Elderly patients and patients with impaired liver function (but normal kidney function) should receive the same dosage as normal adult.
Patients with impaired renal function (creatinine clearance ≤ 80 mL/min): See Table 2.
Click on icon to see table/diagram/imageAdministration: Cravit IV should not be mixed with heparin or alkaline solution (e.g. sodium hydrogen carbonate).
CRAVIT IV is ready for use, and should only be administered by slow intravenous infusion. The infusion time for 500 mg (100 mL) and 750 mg (150 mL) should not be less than 60 minutes (1 hour) and 90 minutes (1.5 hour), respectively. Protection from light is not necessary during infusion time. Once the vial has been opened (rubber stopper perforated) the solution should be used immediately (within 3 hours) in order to prevent any bacterial contamination.
CRAVIT IV should be administered alone unless compatibility with other infusion fluids has been demonstrated.
Compatible infusion solutions include the following: 0.9 % sodium chloride solution, USP, 5 % dextrose injection, USP, 2.5 % dextrose in ringer solution, combination solution for parenteral nutrition (amino acids, carbohydrates, electrolytes).
